Studies with Mustards. Vi. Effects of Alkylating Agents upon Nucleic Acid Synthesis in Bilaterally Grown Sensitive and Resistant Tumors.

of action of an alkylating agent might be facilitated by the availability of an animal neoplasm that responds to treatment with the drug and of a subline of the same neoplasm that is resistant to the drug. Such a system should be useful in pinpointing the metabolic effect of the drug that is responsible for the death of the cells and also in determining why a resistant neoplasm no longer responds to the agent.